Uses

Obtaining a DHEA (dehydroepiandrosterone) blood level in an outpatient setting can be a valuable tool for assessing adrenal function, hormone balance, and overall health optimization. DHEA serves as a precursor to key hormones like testosterone and estrogen, playing a vital role in energy levels, mood regulation, immune function, and metabolism. Monitoring DHEA levels can help identify deficiencies or imbalances that may contribute to fatigue, reduced libido, or cognitive decline. For individuals focused on hormone optimization, anti-aging strategies, or adrenal health, targeted supplementation or lifestyle modifications based on DHEA testing can enhance well-being and prevent potential health issues.

Used in work up women with infertility, amenorrhea, or hirsutism to identify the source of excessive androgen; aid in the evaluation of androgen excess (hirsutism and/or virilization), including Stein-Leventhal syndrome and adrenocortical diseases, including congenital adrenal hyperplasia and adrenal tumor. DHEA-S is not increased with hypopituitarism. It is low in Addison disease.

DHEA-S is a steroid hormone which is produced from the precursor cholesterol in the zona reticularis and broad fascia of the adrenal cortex. The determination of elevated DHEA-S values is an important aid in the diagnosis of hirsutism and virilism. In addition to a differential diagnosis of hirsutism and virilism, further indications for this parameter are all forms of androgenization, hyperprolactinemia, polycystic ovarian syndrome, and the exclusion of an androgen-producing tumor of the adrenal cortex. DHEA-S exhibits only a weak androgenic activity but can be metabolized to more active androgens, such as androstenedione and testosterone, which can indirectly cause hirsutism and virilism.

From 7 years of age onwards, an increase in DHEA-S levels is observed which then gradually after the age of 30 begins to fall again. Only elevated DHEA-S concentrations are of clinical importance; other factors which can be responsible for DHEA-S excess production are genetic enzyme defects of the adrenal cortex (adrenogenital syndrome), hyperplasia of the adrenal cortex, as well as androgen-producing tumors.

The rate of secretion of DHEA-S into the blood stream is only slightly more than the rate observed for DHEA. As a consequence of the DHEA-S half-life of approximately one day, the DHEA-S level is, however, about a thousand-fold greater. DHEA-S is relatively strongly bound to albumin, only a small portion is nonprotein bound, and none appears to be bound to sex hormone-binding globulin (SHBG). Due to its high concentration and low inter- and intra-day variability, DHEA-S is an excellent indicator of adrenal cortex androgen production.

Together with testosterone, DHEA-S assays represent the assay of choice for initial screening tests to determine whether androgen values are elevated in hirsutism. Approximately 84% of the women suffering from hirsutism exhibit elevated androgen levels. The main purpose of this is to exclude the presence of androgen-producing tumors (from the adrenal cortex or the ovaries).

Used in work up women with infertility, amenorrhea, or hirsutism to identify the source of excessive androgen; aid in the evaluation of androgen excess (hirsutism and/or virilization), including Stein-Leventhal syndrome and adrenocortical diseases, including congenital adrenal hyperplasia and adrenal tumor. DHEA-S is not increased with hypopituitarism. It is low in Addison disease.

Preparation

Recommended to stop biotin consumption at least 72 hours prior to the collection of a sample.